Evidence to Support the Claims made in the Patient Leaflet
Section: Discover Noctura 400
- The Noctura 400 sleep mask is an innovative technology which can be used as a therapy for Diabetic Retinopathy and Diabetic Macular Oedema
CE Certificate – can be supplied on request
- The light therapy has been designed so that it doesn’t interfere with your sleep
The spectrum of light chosen for Noctura 400 is that which targets the peak absorption for the rod photoreceptors while minimising the effect on both cone receptors and also ipRGC (intrinsically photosensitive Retinal Ganglion Cells). The peak effect on circadian rhythm, from melanopsin absorption is at a shorter wavelength of 480nm – so sleep interference is minimised as much as possible.
Brainard, George C., et al. “Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor.” The Journal of Neuroscience 21.16 (2001): 6405-6412.
Section: How Noctura 400 works
- When you have diabetes high blood glucose levels and circulation problems can cause changes to the blood vessels in your eyes and lead to Diabetic Retinopathy
- (Cycle of hypoxia diagram)
Shortt et al (2004) Chronic systemic hypoxia causes intra-retinal angiogenesis. Journal of Anatomy 205; 349-358
Section: About Diabetic Retinopathy
- (Pictures illustrating vision with advanced DR)
The originals are from the National Eye Institute https://nei.nih.gov/health/diabetic/retinopathy and are in the public domain widely used all over the internet by eye clinics and Wikipedia https://en.wikipedia.org/wiki/Diabetic_retinopathy
The image is hosted here: https://www.flickr.com/photos/nationaleyeinstitute/7544734198/in/photostream/ and is subject to a basic Creative Commons licence: https://creativecommons.org/licenses/by/2.0/
- Possible Symptoms
Listed in various formats – examples include
Diabetes.co.uk http://www.diabetes.co.uk/diabetes-complications/diabetic-retinopathy.html
Mayo Clinic http://www.mayoclinic.org/diseases-conditions/diabetic-retinopathy/basics/symptoms/con-20023311
Macular Society Guide to DMO – to be supplied
- Diabetic Retinopathy and Diabetic Macular Oedema are serious complications of diabetes and are the most common causes of blindness among people of working age in the UK
DiabetesUK https://www.diabetes.org.uk/Retinopathy